@article {Lorincz2015, title = {Effects of ursolic acid on the structural and morphological behaviours of dipalmitoyl lecithin vesicles}, journal = {Biochimica et Biophysica Acta (BBA) - Biomembranes}, volume = {1848}, number = {5}, year = {2015}, pages = {1092{\textendash}1098}, abstract = {

Effects of ursolic acid on the structural and morphological characteristics of dipalmitoyl lecithin(DPPC)-water system was studied by using differential scanning calorimetry (DSC), small- and wide-angle X-ray scattering (SWAXS), freeze-fracture method combined with transmission electron-microscopy (FF-TEM) and infrared spectroscopy (FT-IR). The surface of the uncorrelated lipid system is rippled or grained and a huge number of small, presumably unilamellar vesicles are present if the UA/DPPC molar ratio is 0.1 mol/mol or higher. Besides the destroyed layer packing of regular multilamellar vesicles, non-bilayer (e.g. cubic or hexagonal) local structures are evidenced by SAXS and FF-TEM methods. The ability of UA to induce non-bilayer structures in hydrated DPPC system originates from the actual geometry form of associated lipid and UA molecules as concluded from the FT-IR measurements and theoretical calculations. Beside numerous beneficial e.g. chemopreventive and chemotherapeutic effect of ursolic acid against cancer, their impact to modify the lipid bilayers can be utilized in liposomal formulations.

}, keywords = {DPPC, Freeze-fractured transmission electron-microscopy (FF-TEM), Kratky camera, Non-bilayer lipid structure, peer-reviewed, Small- and wide-angle X-ray scattering (SWAXS), Ursolic acid}, issn = {0005-2736}, doi = {10.1016/j.bbamem.2015.01.010}, author = {L{\H o}rincz, Andr{\'a}s and Mih{\'a}ly, Judith and N{\'e}meth, Csaba and Andr{\'a}s Wacha and B{\'o}ta, Attila} }